Dantrolene for Malignant Hyperthermia

2016-10-13T18:16:21-05:00April 6th, 2015|Pharmacology, Safety, Toxicology|

Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine, which results in high body temperatures. Dantrolene counters the reaction by blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium.

Dinitrophenol Poisoning

2016-10-13T18:16:27-05:00November 28th, 2014|Toxicology|

Dinitrophenol uncouples oxidative phosphorylation increasing the metabolic rate which can effectively promote weight loss, but unfortunately it has a narrow therapeutic window and is toxic that can lead to mental status changes, multiorgan failure, and death.