Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine, which results in high body temperatures. Dantrolene counters the reaction by blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium.
Dinitrophenol uncouples oxidative phosphorylation increasing the metabolic rate which can effectively promote weight loss, but unfortunately it has a narrow therapeutic window and is toxic that can lead to mental status changes, multiorgan failure, and death.
Inhalation of noxious gases and fumes, including ammonia, nitric acid, sulfur dioxide, and chlorine gas can cause pulmonary injury including direct toxic effects and secondary ARDS requiring mechanical ventilation and permanent respiratory difficulties.
The Hennepin Regional Poison Center have published a case series of asystolic cardiac arrest after treatment with intralipid. The authors readily acknowledge the difficulty of assigning causality, and caution against dramatic practice changes.
Diagnosis of the poisoned patient can often be accomplished before toxicologic laboratory tests by obtaining a detailed history and directed physical exam. In this second of three articles, we will examine the toxicology clues revealed by the skin.
Diagnosis of the poisoned patient can often be accomplished before toxicologic laboratory tests by obtaining a detailed history and directed physical exam. In this first of three articles, we will examine the toxicology clues that can be found in eyes, hair, nails, and tongue.
Glucagon Emergency Kit is an an injectable form of glucagon available for treatment of hypoglycemia, beta-blocker overdose, calcium channel overdose, or impacted food bolus. Knowing how to preparation the Glucagon Emergency Kit is time critical knowledge in the ED.
Toxicology can devour a disproportionate amount of studying time in preparation for the boards. Unlike many other subjects however, it lends itself to some word associations and other high value studying. This list has been compiled to facilitate some rapid review.
Ingestions of greater than 5000 mcg is considered a potentially toxic dose. Acute overdoses tend to be well tolerated. The symptoms of elevated T4 are not evident until 2-5 days following ingestion. Measured levels do not correlate well with either ingestion amounts or development/sev
Fascinating list of books that lets you understand the importance infectious diseases have had on the world and how disease have shaped the history of politics, nations, wars, migrations, and culture. Topics include malaria, smallpox, cholera, and more.