Dantrolene for Malignant Hyperthermia

2016-10-13T18:16:21-05:00April 6th, 2015|Pharmacology, Safety, Toxicology|

Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine, which results in high body temperatures. Dantrolene counters the reaction by blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium.

Dinitrophenol Poisoning

2016-10-13T18:16:27-05:00November 28th, 2014|Toxicology|

Dinitrophenol uncouples oxidative phosphorylation increasing the metabolic rate which can effectively promote weight loss, but unfortunately it has a narrow therapeutic window and is toxic that can lead to mental status changes, multiorgan failure, and death.

Ammonia Inhalation Injury

2017-09-15T22:28:20-05:00October 14th, 2014|Case, Pulmonary, Toxicology|

Inhalation of noxious gases and fumes, including ammonia, nitric acid, sulfur dioxide, and chlorine gas can cause pulmonary injury including direct toxic effects and secondary ARDS requiring mechanical ventilation and permanent respiratory difficulties.

Physical Exam Clues in Toxicology – Part 2: Skin

2014-10-17T03:11:14-05:00December 18th, 2013|Toxicology|

Diagnosis of the poisoned patient can often be accomplished before toxicologic laboratory tests by obtaining a detailed history and directed physical exam. In this second of three articles, we will examine the toxicology clues revealed by the skin.