Dantrolene for Malignant Hyperthermia

2016-10-13T18:16:21-05:00April 6th, 2015|Pharmacology, Safety, Toxicology|

Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine, which results in high body temperatures. Dantrolene counters the reaction by blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium.