Dantrolene for Malignant Hyperthermia

2016-10-13T18:16:21-05:00April 6th, 2015|Pharmacology, Safety, Toxicology|

Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine, which results in high body temperatures. Dantrolene counters the reaction by blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium.

tPA Mixing Tutorial

2016-10-13T18:16:36-05:00May 20th, 2013|Pharmacology, Procedures|

Alteplase (tPA) is used infrequently and often only in emergent situations. Nurses and physicians unfamiliar with preparing the medication may need to high pressure situations. This tutorial includes step-by-step instructions for preparing and mixing tPA.

Emergency Department Medication Utilization and Cost

2016-10-13T18:16:37-05:00April 3rd, 2013|Pharmacology|

I practice at Hennepin County Medical Center, a large inner city academic Level 1 Trauma Center. Like all such facilities we have been under a tremendous pressure to reduce costs, and pharmaceutical costs have been a large target. To make us physicians more aware of our prescribing