Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine. A genetic mutation in the ryanodine receptor causes sequestration of intracellular calcium and rigid muscle contractions, which requires large quantities of ATP which is is replenished by uncontrolled oxidative metabolism. The result is heat production and high body temperatures.
Dantrolene acts at the ryanodine receptor blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium, thereby countering the effects of the malignant hyperthermia. Although, Dantrolen