A paper by Niklas Nielsen et al titled “Targeted temperature management at 33°C versus 36°C after cardiac arrest”. Published online by The New England Journal of Medicine on November 17, 2013 has brought a lot of attention to the use of therapeutic hypothermia for post-cardiac arrest cares. It stormed through the social media channels. Within days, EMRAP, Emcrit, Life in the Fast Lane, St. Emlyn’s, Intensive Care Network and most other ED/critical care websites and podcasts had devoted time to covering it. It may very well be practice changing in emergency departments and ICUs through throughout the world. Or maybe not. Before we can figure out what “truth” this research study may have uncovered, we will look at the development of therapeutic hypothermia and what the literature has already told us.

Download Episode: ResusReview-Podcast-02-Therapeutic-Hypothermia-History-and-TTM-Trial.mp3

Chapter 1 The Beginning

Ancient societies had long figured out that hypothermia was useful for acute hemorrhage control. But Hippocrates had figured out a way to use the body’s heat production as a diagnosis tool. He would take his patients, and cake them in mud. The areas that dried first were warmer. “In whatever part of the body excess of heat or cold is felt, the disease is there to be discovered.” And once they figured out the diseased are, the proceeded to inflict their “cures” on the patient.

Typhoid fever whic