Presentation — Hell or High Lactate

Outline Presentation


Selected References (Key Readings)

  • Review Article

    • Suetrong B, Walley KR. Chest 2016; 149(1):252-261. Lactic Acidosis in Sepsis: It’s Not All Anaerobic. Implications for Diagnosis and Management.
    • Levy, Bruno. Current Opinion in Critical Care 2006, 12:315. Lactate and shock state: the metabolic view.
  • Biochemistry of Lactate Production

    • Robergs RA, Ghiasvand F, Parker D. Am J Physiol Regul Integr Comp Physiol 287: R502–R516, 2004. Biochemistry of exercise-induced metabolic acidosis.
    • James JH, Luchette FA, McCarter FD, Fischer JE. Lancet 1999;354:505. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis.
    • Lindinger MI, Kowalchuck JM, Heigenhauser GJF. Am J Physiol Regul Integr Comp Physiol 289: R891, 2005. Applying physicochemical principles to skeletal muscle acid-base status.
  • Lactate Measurements

    • Lavery RF, Livingston DH, Tortella BJ, Sambol JT, Slomovitz BM, Siegel JH. The utility of venous lactate to triage injured patients in the trauma center. J Am Coll Surg 2000;190:656-64.
    • Younger JG, Falk JL, Rothrock SG. Relationship between arterial and peripheral venous lactate levels. Acad Emerg Med 1996;3:730-4.
    • Middleton P, Kelly AM, Brown J, Robertson M. Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate. Emerg Med J 2006;23:622-4.
    • Jones AE, Leonard MM, Hernandez-Nino J, Kline JA. Determination of the effect of in vitro time, temperature, and tourniquet use on whole blood venous point-of-care lactate concentrations. Acad Emerg Med 2007;14:587-91.
  • Lactate Elevation Association with Mortality

    • Nichol AD, Egi M, Pettila V, et al. Relative hyperlactatemia and hospital mortality in critically ill
      patients: a retrospective multi-centre study. Crit Care 2010;14:R25.
    • Mikkelsen ME, Miltiades AN, Gaieski DF, et al. Serum lactate is associated with mortality in severe
      sepsis independent of organ failure and shock. Crit Care Med 2009;37:1670-7.
    • Mizock BA, Falk JL. Lactic acidosis in critical illness. Crit Care Med 1992;20:80-93.
    • Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. Occult hypoperfusion and mortality in
      patients with suspected infection. Intensive Care Med 2007;33:1892-9.
    • Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency
      department patients with infection. Ann Emerg Med 2005;45:524-8.
    • Cady LD, Jr., Weil MH, Afifi AA, Michaels SF, Liu VY, Shubin H. Quantitation of severity of critical
      illness with special reference to blood lactate. Crit Care Med 1973;1:75-80.
    • Aduen J, Bernstein WK, Khastgir T, et al. The use and clinical importance of a substrate-specific
      electrode for rapid determination of blood lactate concentrations. JAMA 1994;272:1678-85.
  • Lactate Clearance

    • Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturat